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Thirty cancer patients (14 males, 16 females) with the average age of 46.93 years were studied. They were treated by gamma-partial body irradiation Iradiation doses (tumor doses) ranged from :3000-6600 rade in 3—6 weeks.
Total serum-protein was determined for each patient before, during and after radiotherapy by Biuret method. Gamma-globulin was determined by electrophoresis and immunoglobulins were determined by the single radial immunodiffusion technique.
The experimental results showed that gammablobulin was decreased during and after radiotherapy. The reduction of gammaglobulin in 86.66% cases was 14.11% which indicates that the amount of immunoglobulins were also changed.
75. % of 28 patients showed a 70.41 mg/lOOml reduction of IgA after radiotherapy. This result shows that during and after radiotherapy the amount of IgA is reduced to below the normal level.
57,14% of 28 patients showed a 297. 02 mg/100 ml reduction OF IgG and 39.28% of 28 patients showed a 44.09 mg/lOOml reduction of 1gM after radiotherapy. These results show that although the concentration of IgG and 1gM bave been
reduced after radiotherapy, they are still above the normal levels. Due to precocious symptoms caused by radiation of tentative cancer
patients (especially) those suffering from Qesophagus cancer) a lack of appetite was observed among the patients.
The results showed that there was no reduction in total protein before, during and after radiotherapy. Therefore, precocious symptoms of radiation cannot be an effective factor in the reduction of gammaglobulin and immnunoglo— bulins (IgM,IgG),the reduction of IgA in patients during and after radiotherapy could have some side-effects.