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In this study by analyzing laboratory data in gas-filled rocks, it is shown that the Poisson’s ratio (PR) increases with increasing differential pressure. Also in liquid-saturated rocks the relationship is opposite; PR decreases with increasing differential pressure. Thus as sediments pass through the transition zone from load bearing to a suspension, the Poisson’s ratio is expected to rise almost exponentially. Therefore, the none-linear portions of these curves at low differential pressure are the most relevant to pore pressure at deeper depths. This result will have a significant impact for deepwater sediments hazards, where pre-stack inversion of P-wave seismic data for Poisson’s ratio and diagnostic charts is used as a pressure indicator.