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Dezful Embayment located in Southwest of Iran is one of the most potential areas for exploration and development of hydrocarbon reservoirs in the world. There are several source rock units with different geological ages. Burial and thermal history modeling was performed to determine timing of hydrocarbon generation in the Pabdeh source rock in Dezful Embayment. Geology and sequence stratigraphic analysis of borehole data including drill-cuttings provided fundamental constraints for burial history reconstruction. In addition, estimates of exhumation from log-derived compaction data provide key insight into depositional patterns. One-dimensional and two-dimensional models of thermal evolution were derived from the burial history and calibrated with vitrinite reflectance, thermal conductivity, surface and bottom-hole temperature measurements, as well as with paleoclimate data. The resulting thermal history models were combined with the measured geochemical parameters in order to determine the timing of hydrocarbon generation for the candidate source rock (Pabdeh Formation). Results were compiled in maps and cross-sections representing multiple stages of basin evolution. Most hydrocarbon generation in the Dezful Embayment generally took place in Kazhdumi Formation and partly in Pabdeh Formation. The Pabdeh Formation is the most youngest source rock in Dezful Embayment with type II and a mixture of type II and III Kerogens and has reached oil generation at most parts of the Dezful Embayment. Higher amounts of hydrocarbon were generated at deep and central part related to higher maturity levels. Based on thermal maturity modeling, Pabdeh Formation is early mature to mid mature.